Abstract
Background Rapid diagnostic tests (RDTs) for malaria are increasingly being used for management of patients. Different studies have shown significant failure rate of RDTs, especially in children and in areas of low malaria transmission. In this study, we sort molecular answers to RDT failure by re-screening RDT negative samples for malaria at genus and species level as well as for diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP-2) and lactate dehydrogenase (pLDH). PfHRP-2 and pLDH are the malaria target antigens for the commonly used commercial RDTs.
Highlights
Rapid diagnostic tests (RDTs) for malaria are increasingly being used for management of patients
Molecular answers to the high failure rate of malaria RDTs
It is concluded that, 50% of the RDT failures are attributable to the detection threshold of the RDTs
Summary
Rapid diagnostic tests (RDTs) for malaria are increasingly being used for management of patients. Different studies have shown significant failure rate of RDTs, especially in children and in areas of low malaria transmission. We sort molecular answers to RDT failure by re-screening RDT negative samples for malaria at genus and species level as well as for diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP-2) and lactate dehydrogenase (pLDH). PfHRP-2 and pLDH are the malaria target antigens for the commonly used commercial RDTs
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