Abstract
Molecular and Immunological Investigation of Canine Distemper Virus (CDV) and Its Co- Infection with Canine Parainfluenza Virus Type 2
Highlights
Canine distemper virus (CDV) is a member of the family Paramyxoviridae, which can infect certain epithelial cell lines of the respiratory, gastrointestinal, or nervous systems [1]
A high prevalence (55.6%) of CDV has been reported among the rural dogs in the north of Iran [3]
There were 29 and one positive cases among symptomatic and asymptomatic dogs based on the results of rapid distemper immunochromatography kits, respectively
Summary
Canine distemper virus (CDV) is a member of the family Paramyxoviridae, which can infect certain epithelial cell lines of the respiratory, gastrointestinal, or nervous systems [1]. CDV inhibits immunity and its receptor is the signaling lymphocyte activation molecule 4 (SLAM 4) [5]. Such condition often gives other microorganisms a chance of occurrence and infection. The present study was performed to detect CDV by the genomic and immunological methods and investigate its co- infection with canine parainfluenza virus type 2 (CPiV-2). After RT_PCR assay, in the first group, 37 samples were reported as CDV positive and 11, CpiV-2 positive. Conclusion: In the present study, using statistical tests, we observed no association between distemper and CpiV-2
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