Abstract
Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors. In particular, irisin is capable of protecting hippocampus. Since this area is the region of the brain that is most susceptible to Alzheimer’s disease (AD), such beneficial effect may inhibit or delay the emergence of neurodegenerative diseases, including AD. Also, the factors engaged in irisin formation appear to suppress Aβ aggregation, which is the pathological hallmark of AD. This review is based on the hypothesis that irisin produced by physical exercise helps to control AD progression. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD progression in human.
Highlights
Alzheimer’s disease (AD) is a devastating age-associated neurodegenerative disorder characterized by progressive cognitive and functional decline
Physical exercise slows the neurodegeneration-induced decline of executive functioning [9], and many studies have highlighted the effects of exercise in various organs, such as the liver, brain, adipose tissue, and heart
These results suggest that irisin contributes to the neuroprotective effects of physical exercise in cerebral ischemia and is a promising agent for the prevention and treatment of ischemic stroke
Summary
Alzheimer’s disease (AD) is a devastating age-associated neurodegenerative disorder characterized by progressive cognitive and functional decline. Molecules 2018, 23, 3229 and other peptides that function in manner similar to hormones [11] These secretions may underlie the beneficial effects [11]. Hundredsmay of secretome components skeletal muscle are involved similar to hormones These secretions underlie the beneficial of effects of exercise. Hundreds of in muscle communication with other organs [10] Among these components, irisin has attracted secretome components of skeletal muscle are involved in muscle communication with other organsgreat attention, as itcomponents, has recentlyirisin beenhas identified as great a muscle-derived released skeletal. Irisin has attracted secretome components of skeletal muscle are involved in muscle communication with other organsgreat attention, as itcomponents, has recentlyirisin beenhas identified as great a muscle-derived released skeletal Among these attracted attention, as itmyokine has recently beenfrom identified as muscle immediately after exercise. Discusses the beneficial of irisin and its potential protective effects against AD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
