Abstract
Basic and acidic fibroblast growth factors (FGFs) are two closely related peptides of Mr =16000 that act as potent mitogens and differentiation factors or a wide variety of mesoderm and neuroectoderm derived cells. Basic FGF (bFGF pI 9.6) was first identified by its ability to cause the proliferation and phenotypic transformation of BALB-C 3T3 fibroblasts (Gospodarowicz,1974;Gospodarowicz and Moran,1974), while acidic FGF (aFGF, pI 5.6) was first identified by its ability to cause the proliferation and delayed differentiation of myoblasts (Gospodarowicz et al.,1975). It was later rediscovered on the basis of its ability to stimulate endothelial cell proliferation (Lemmon et al.,1982; Maciag et al.,1978).
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