Abstract
Recent progress in molecular engineering has contributed to the great progress of medicine. However, there are still difficult problems constituting a challenge for molecular biology and biotechnology, e.g. new generation of anticancer agents, alternative biosensors or vaccines. As a biotechnological tool, bacteriophages (phages) offer a promising alternative to traditional approaches. They can be applied as anticancer agents, novel platforms in vaccine design, or as target carriers in drug discovery. Phages also offer solutions for modern cell imaging, biosensor construction or food pathogen detection. Here we present a review of bacteriophage research as a dynamically developing field with promising prospects for further development of medicine and biotechnology.
Highlights
Recent progress in molecular engineering has contributed to the great progress of medicine
There are still difficult problems constituting a challenge for molecular biology and biotechnology, e.g. new generation of anticancer agents, alternative biosensors or vaccines
We present a review of bacteriophage research as a dynamically developing field with promising prospects for further development of medicine and biotechnology
Summary
Recent progress in molecular engineering has contributed to the great progress of medicine. Phage display is a molecular technique that allows expression of exogenous proteins on a bacteriophage surface. Co-infection of the bacterial host cell by a phagemid and a phage produces hybrid virions displaying only a few copies of the fusion coat protein to the majority of wild-type structural coat proteins (Pande et al 2010). Types 33, 66, 88 allow one to combine fusion proteins and wild proteins in the same capsid, but they are expressed from the same phage genome (Bratkovic 2010).
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