Abstract
Hydroxy-alpha-sanshool (sanshool), the active ingredient in plants of the prickly ash plant family, induces robust tingling paresthesia and numbing analgesia. Previous studies have shown that sanshool activates the cell bodies of a subset of somatosensory neurons, including putative nociceptors and light touch mechanoreceptors. We used the skin-nerve preparation to examine the pattern and intensity with which the sensory terminals of cutaneous neurons respond to sanshool. We found that sanshool excites virtually all D-hair afferents, a distinct subset of ultra-sensitive light touch receptors in the skin, and targets novel populations of Abeta and C-fiber nerve afferents.
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