Abstract
The transduction of physical forces into cellular electrical signals is fundamental to a wide breadth of biology including the classic senses of touch, pain, hearing, and balance; less conspicuous sensations of proprioception, blood pressure, and osmolarity; and basic aspects of neural growth, signaling, and death. In this talk, I will discuss recent work aimed at understanding the basis of mechanosensation and volume regulation in the nervous system. First, I will present a model for the mechanism of membrane tension sensing and physiological roles of a mechanosensitive potassium channel based on a combination of structural, electrophysiological, and localization data. Second, I will present a model for ionic strength sensing and channel gating in a family of volume regulated anion channels based on structural and functional studies.Support or Funding InformationNew York Stem Cell Foundation ‐ Robertson Neuroscience Investigator Award, McKnight Scholar Award, Klingenstein‐Simons Fellowship Award, NIGMS New Innovator Award, Rose Hill Innovator Award
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