Abstract
In the present study, we characterize the molecular structure of the GABA A receptor in pancreas, islets, α and β cells, and in RIN 1046-38 cells. Using the polymerase chain reaction and specific primers for 11 out of the 15 subunits known so far, that may contribute to the composition of the GABA A receptors, we demonstrate that pancreas and its cellular components, as well RIN 1046-38 cells, might contain a GABA A receptor resulting from all the possible combinations in a pentameric configuration of the subtypes α1, α2, α3 of the α subunit family, βl, β2, β3 subtypes of the β subunit family, δ subunit and γ2 subtype of the γ subunit family. The presence of the γ2 subunit renders the GABA A receptors potentially sensitive to allosteric modulators.
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