Abstract
This article has no abstract.
Highlights
The immediate-early protein tristetraprolin (TTP) is induced by numerous extracellular stimuli and during some apoptotic events
We have determined that various cell types undergo programmed cell death in response to constitutive low-level TTP/TIS11 protein expression
TTP alone is able to sensitize cells to TNFα mediated cell death, leading us to postulate that different family members may receive or propagate death stimuli in different ways
Summary
The immediate-early protein tristetraprolin (TTP) is induced by numerous extracellular stimuli and during some apoptotic events. TTP and the related proteins TIS11b and TIS11d (TTP/TIS11 proteins) are members of a family with highly conserved Cys3His zinc fingers that are associated with RNA binding. Lack of TTP causes an inflammatory syndrome that is mediated by TNFα 1, and evidence indicates that TTP can bind and destabilize TNFα and other cytokine mRNAs2. All three TTP/TIS11 proteins possess this activity and it is present within the zinc finger region. Several precedents suggest that TTP/TIS11 proteins may be implicated in survival, growth, or apoptotic pathways; a model we have addressed in this study
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