Molecular Analysis of The Rs1800629 Polymorphic Variant in the TNF-Gene in The Pathogenesis of Fetal Loss Syndrome

N N Mavlyanova

doi:10.34297/ajbsr.2020.10.001536

Abstract

This paper presents molecular genetic research of the TNF- gene polymorphism in pregnant women with fetal loss syndrome. Analysis of molecular genetic research showed that allele A and heterozygous genotypes of the rs1800629 polymorphism in the TNF- gene may be markers of a tendency for an increased risk of developing fetal loss syndrome in Uzbekistan. There is a tendency towards an increase in the frequency of the unfavorable allele A of the TNF- gene in female patients with a severe form of Fetal Loss Syndrome (FLS) as compared with its mild case [1,2].

Highlights

The research priority in pathologies in obstetrics and gynecology is studying the state of formation of the ‘mother-placenta-fetus’ functional system, which is the birth of a healthy infant [3,4,5]
Among 51 pregnant women, Fetal Loss Syndrome (FLS) was diagnosed in 41 ones, which accounted for 80.4% of cases
To assess the clinical course of fetal loss syndrome, we used the working classification used in Fetal Growth Restriction Syndrome (FGRS)

Summary

Introduction

The research priority in pathologies in obstetrics and gynecology is studying the state of formation of the ‘mother-placenta-fetus’ functional system, which is the birth of a healthy infant [3,4,5]. Studies have demonstrated the role of the proinflammatory cytokine TNF-α in the regulation of apoptosis in the early stages of gestation, its participation in the regulation of the invasion of trophoblast cells is known [7,16,17,18]. This factor enhances the proliferation of T and B cells, the formation of adhesive molecules, acute phase proteins, and activates fibroblasts. TGF-β, isolated from homogenates of placental tissue, is recognized as a topical factor regulating the proliferation and invasion of cytotrophoblast in the placental-uterine region. The study of the distribution of rs1800629 polymorphism in the TNF- gene in fetal loss syndrome is an urgent problem in obstetrics and gynecology

Material and Methods of The Research

Results of The Research

Conclusion