Abstract
5570 Background: Non-epithelial malignancies of the ovary account for <2%–4% of all ovarian tumors. The classification of non-epithelial ovarian cancer can be broadly divided into two histological subtypes, ovarian germ cell tumors (OGCTs) and ovarian sex cord stromal tumors (OSCSTs). Molecular phenotypes of these groupings may identify genetic susceptibilities to existing therapies and thus improve patient care. Methods: 275 non-epithelial ovarian cancers (non-EOC) were profiled by Caris Life Sciences between 2009 and 2013 using a multiplatform approach. Within this cohort, patients could be further grouped according to histopathological subtypes, particularly OGCTs (n=42) and OSCSTs (n=217). Testing of FFPE tissues included a combination of sequencing (Sanger, NGS and pyrosequencing), protein expression (IHC), gene amplification (CISH or FISH), and/or RNA fragment analysis. Results: Of interest, the frequency of positive hormone receptor over-expression was higher in OSCSTs than OGCTs(AR 76%v 0%, PR 90%...
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