Abstract
Objective: Uterine clear cell carcinoma (UCC) and uterine malignant mesodermal mixed tumor (UMMMT), also known as uterine carcinosarcoma, are rare but clinically aggressive histologic variants of endometrial carcinoma. The molecular alterations in the oncogenic P13K-alpha pathway have not been studied in detail in these subtypes. In prior studies, 80% of PIK3CA mutations were found in exons 9 and 20 and the remaining 20% were found in exons 1-7. Our objective was to analyze UCC and UMMMT cases for mutations in PIK3CA in exons 1-9 and 20.
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