Abstract
Caryocar brasiliense, popularly known in Brazil as “pequi”, is a species widely distributed in the Brazilian Cerrado. The seeds are surrounded by a woody endocarp coated with a yellow fleshy mesocarp rich in oil and vitamin A, whose oil has a useful role in the treatment of skin aging and protection of human skin against UV-induced damage and skin hydration. The aim of this study was to evaluate the effect of cosmetic formulations containing pequi oil (Caryocar brasiliense) on skin hydration, after a single application. Hydration effect assessment was performed by applying the formulations under study (Control – no formulation, vehicle, and vehicle + pequi oil) onto forearm skin of 30 human volunteers. Skin capacitance and Transepidermal Water Loss (TEWL) measurements were analyzed before, and at 1, 2 and 3 hours after, a single application. Evaluation results of a single application of the vehicle containing pequi oil showed an increase in stratum corneum water content, indicating a skin moisturizing effect. Results of the evaluation of immediate effects of TEWL demonstrated that the vehicle containing pequi oil significantly increased skin moisture during the 3 h evaluation period. The formulations containing pequi oil showed clinical efficacy, increasing stratum corneum water content and enhancing skin barrier function.
Highlights
The skin has numerous functions and the stratum corneum (SC) is the most important skin barrier against exogenous physical and chemical influences whileW
Considerable interest has been generated by its antioxidant capacity and several studies with vegetal species have been published recently (Gianeti et al, 2012; Zia-Ul-Haq et al.,2012). In this context the aim of the present study was to evaluate the effect of cosmetic formulations containing pequi oil on skin hydration, after a single application, by using noninvasive bioengineering techniques, as well as to assess their effects on skin hydration properties: skin barrier function as measured by transepidermal water loss and stratum corneum hydration determined by capacitance measurements
The active compounds used in cosmetic skin hydration can be divided into two major groups: hydrophilic and lipophilic agents, that act via four main mechanisms: by occlusion, humectant, hydration active rearrangement of stratum corneum and by inducing the formation of aquoporins (Bonté, 2011; Ribeiro et al, 2010; Caussin et al, 2009)
Summary
The aim of this study was to evaluate the effect of cosmetic formulations containing pequi oil (Caryocar brasiliense) on skin hydration, after a single application. In this context the aim of the present study was to evaluate the effect of cosmetic formulations containing pequi oil on skin hydration, after a single application, by using noninvasive bioengineering techniques, as well as to assess their effects on skin hydration properties: skin barrier function as measured by transepidermal water loss and stratum corneum hydration determined by capacitance measurements
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