Abstract
In this work, a novel methodology to determine moisture transport coefficients for MMC PH101 tablets is presented. Absolute permeability, moisture diffusion, moisture transfer, and water vapor permeability coefficients were estimated on compressed powder tablets produced with different compression pressures (20 MPa to 200 MPa with an interval of 20 MPa). The ASTM D6539 standard test was used to measure the absolute permeability. The moisture transfer coefficient was determined from measured absolute permeability. The moisture diffusion coefficient was obtained with the tablet average pore radius, which was determined with the water droplet penetration method. Descriptive and phenomenological models derived from the measurements were confronted with existing and adopted models, and a good agreement was found. The obtained models are of the function of the microstructural properties of the tablet (average pore radius and average porosity). The tablet average porosity was found to be the principal parameter that governs the behavior of the moisture transport coefficients. The findings of this study might be applicable to obtain a series of input parameters for modelling software, such as COMSOL Multiphysics®, to infer delamination, sticking, and failure propensity from the effect of moisture.
Highlights
IntroductionZografi et al [8] reported a moisture content of 5–6% for microcrystalline cellulose (MCC) during routine handling under ambient conditions of 40–50% relative humidity
Partheniadis et al, through monitoring the weight and dimensional expansion under dynamic vapor sorption, reported that the weight and dimension of pyridostigmine bromide tablets increases with the ambient relative humidity due to the increase of the tablet moisture [9]
The mean of three measurements was calculated; the value obtained for the powder moisture content was 3.2 wt.% at a relative humidity of 38% and temperature of 25 ◦ C
Summary
Zografi et al [8] reported a moisture content of 5–6% for microcrystalline cellulose (MCC) during routine handling under ambient conditions of 40–50% relative humidity. Sun et al [1] found variations in MCC properties within the small 3–5% moisture range but concluded that this range was still ideal, as more significant property changes were observed at higher moisture levels. These previous studies show how the moisture content of pharmaceutical powder can change during handling and manufacturing
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