Abstract
Buschke-Löwenstein tumor (BLT), or giant condyloma acuminatum, is a rare sexually transmitted disease with a potentially fatal course. The virus responsible for condyloma is human papillomavirus, usually serotype 6 or11. ABLT is always preceded by condyloma acuminatum and may occur at any age after puberty. It is characterized by invasive growth and recurrence after treatment, and malignant transformation is possible. There is no general agreement on the choice of treatment for this tumor. Wide radical excision with plastic reconstruction of skin defects seems to be the best treatment, while adjuvant therapies, such as radiotherapy and immunotherapy, may achieve good results, but their effectiveness is still unclear. We report 3 cases of 32- and 40-year-old males and a 38-year-old female with an approximate 5-year history of a perianal BLT.
Highlights
It was first described as a penile lesion by Abraham Buschke in 1896, in 1925, Buschke and his assistant, Löwenstein reported on giant condyloma acuminatum (GCA) as benign carcinoma-like condyloma acuminatum [1]
GCA has a high propensity for local tumrence and considerable risk of neoplastic transformation into fully invasive squamous cell carcinoma (SCC) [6]
Infiltration of the tumor basis, or lymph node enlargement may cause the clinician to suspect a malignant transformation into micro-invasive carcinoma or into well-differentiated keratinizing squamous cell carcinoma, which occurs in about 30% of cases
Summary
It was first described as a penile lesion by Abraham Buschke in 1896, in 1925, Buschke and his assistant, Löwenstein reported on giant condyloma acuminatum (GCA) as benign carcinoma-like condyloma acuminatum [1]. Ackermann coined the term VC for well-differentiated, low-grade carcinoma of oral mucosal viral warts [4]. It is a rare sexually transmitted disease with an incidence of probably 0.1% in the general population. GCA has a high propensity for local tumrence and considerable risk of neoplastic transformation into fully invasive squamous cell carcinoma (SCC) [6]. Most authors recommend early control of local disease by radical excision, and eventual abdominoperineal resection in cases of recurrence, pelvic invasion or malignant transformation [7]. The cases are reported here of 2 males aged 32 and 40 years and a 38-year-old female with a perianal Buschke-Löwenstein tumor
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