Abstract

Although myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disease, it may occur as a paraneoplastic syndrome in rare instances. A 80-year-old woman presented with paresthesia and weakness of four extremities for 10 days. Spine magnetic resonance imaging showed longitudinally extensive transverse myelitis. Laboratory tests revealed positive MOG antibodies. Both high-dose intravenous methylprednisolone and plasma exchange were not effective and further evaluation showed lymphoma. Herein, we reported a case of MOG-positive paraneoplastic myelopathy with lymphoma.

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