Abstract

Gene expression is regulated by transcription factors (TFs) and chromatin modifiers such as histone acetyltransferases (HATs). Pessoa Rodrigues et al. revealed the role of the Males absent on the first (MOF) HAT in hematopoietic stem cell (HSC) differentiation into red blood cells. This work raises interesting questions about how MOF controls other hematopoietic differentiation processes.

Highlights

  • Gene expression is regulated by transcription factors (TFs) and chromatin modifiers such as histone acetyltransferases (HATs)

  • Pessoa Rodrigues et al revealed the role of the Males absent on the first (MOF) HAT in hematopoietic stem cell (HSC) differentiation histones, such as phosphorylation, methylation, ubiquitination, and acetylation [2]

  • MOF’s Role in HSC Differentiation Due to the embryonic lethality of the Mof knockout, researchers had to rely on conditional loss-of-function tools and on heterozygous Mof mouse mutants to study its role in adult tissues

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Summary

Introduction

MOF Histone Acetyltransferase in Blood Cell Development Gene expression is regulated by transcription factors (TFs) and chromatin modifiers such as histone acetyltransferases (HATs). Pessoa Rodrigues et al revealed the role of the Males absent on the first (MOF) HAT in hematopoietic stem cell (HSC) differentiation histones, such as phosphorylation, methylation, ubiquitination, and acetylation [2].

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