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Abstract
Yahom Tultavai is a Thai traditional medicine that has been widely used for the treatment of nausea, vomiting, dizziness and weakness in aged-people, especially. Its formula contains several medicinal plants, and one of them is Kaempferia galanga L., which has ethyl-p-methoxycinnamate (EPMC) as its major compound. Recently, several herbs and traditional medicines have been reported to demonstrate herbal-drug interaction with conventional medicines. This study aims to investigate the effect of Yahom Tultavai extracts on hepatic cytochrome P450 enzymes and pentobarbital-induced sleeping in mice. Three extracts of Yahom Tultavai, using dichloromethane, methanol and distilled water as solvents were orally administered for 28 days prior to determine CYP1A1, CYP1A2, CYP2B, CYP2E1 and CYP3A4 activities. All three extracts significantly inhibited CYP1A1, CYP1A2 and CYP 2E1 activities, but only dichloromethane extract enhanced CYP2B activity. In addition, all three extracts had no effect on CYP3A4 activity. As an indicator for metabolic drug interaction, pentobarbital-induced sleeping time was decreased in connection with the induction of CYP2B activity between 7 and 28 days of dichloromethane extract and EPMC-treated animals when compared to control. In conclusion, Yahom Tultavai extracts affected hepatic microsomal CYP enzyme activities and reduced pentobarbital-induced sleeping time in mice. The results suggest that Yahom Tultavai may potentially cause herbal and conventional drug interaction, which can affect the clinical implication of drug action. Therefore, the co-administration of Yahom Tultavai with certain drugs should be carefully considered.
Highlights
Yahom is a common name that refers to Thai traditional medicine which usually contains many medicinal plants
By using mobile phase A, dichloromethane extract showed the most numbers of constituents, which was more than 17 peaks of different retention times with the prominent peak of EPMC at 4 mg% concentration (Figure 1A and 1B)
This study demonstrated that Yahom Tultavai affected hepatic microsomal cytochrome P450 (CYP) enzyme activities and pentobarbital-induced sleeping in mice
Summary
Yahom is a common name that refers to Thai traditional medicine which usually contains many medicinal plants. Yahom has been widely used among the aged-population for the treatment of nausea, vomiting, dizziness, weakness and fainting symptom. Yahom Tultavai contains more than 10 powdered medicinal ingredients including Kaempferia galanga L. This plant belongs to the Zingiberaceae family, and is widely found in South India and Southeast Asia. It is commonly used as a flavouring plant in Yahom, and its major constituent is ethyl-p-methoxycinnamate (EPMC) (Teawtrakul et al, 2005). Given its many potential utilisations, it may create drug interactions
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