Abstract
Local application of serotonin (5-hydroxytryptamine, 5-HT) to the soma of command neurons LPa2, LPa3, PPa3, and PPa2 of edible snail Helix lucorum reversibly decreased acetylcholine-induced inward current in these neurons. NAN-190 and methiothepin, antagonists of 5-HT1 serotonin receptors, prevented this modulatory effect of 5-HT. By contrast, LY-53.857, ICS-205.930, and SDZ-205.557, antagonists of 5-HT2, 5-HT3, and 5-HT4 serotonin receptors, respectively, produced no effect on the modulatory effect of serotonin. The data confirm the presence of modulator 5-HT1 serotonin receptor on the soma of command neurons of Helix pomatia.
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