Abstract
Placement of cotton-thread impregnated with beeswax containing methylcholanthrene (approx. 600 μg) inside the canal of uterine cervix of virgin adult mice results in the emergence of precancerous and cancerous lesions in the cervical epithelium. Employing this experimental cervical carcinogenesis model system, the present study evaluates the modulatory influence of exogenous 17β-estradiol on the incidences of precancerous and cancerous lesions in the cervical epithelium. When 17β-estradiol was administered weekly at the dose levels of 0.01 μg, 0.1 μg, 5 μg and 50 μg for 16 weeks following carcinogen-thread insertion, the cervical carcinoma incidences, as compared to that in positive control mice (76.1%), were 66.6%, 61.5%, 55.5% and 42.1%, respectively. The decline in the incidence of carcinomas at 50 μg/week dose level was significant (P < 0.05). Hyperplastic and dysplastic changes did not show any definite correlation with the various treatments.
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