Modulatory Effects of Vitamin C on Enrofloxacin Induced Chromosome Damage and AgNOR Counts in Chick Bone Marrow Nuclei

Abstract

Quinolones are broad spectrum antibiotics and are widely used in veterinary practice. But because of continuous improvement in their bactericidal and metabolic properties, it resulted in an increased amount of genotoxicity among animals. Vitamin C is a well-known antioxidant and a free radical scavenger and protects the cell from endogenous oxidative DNA damage. The aim of the study was to find the modulatory effect of Vitamin C against the enrofloxacin induced chromosomal aberrations and nuclear damage. The toxicity includes a significant decrease in mitotic index and increases in the number of chromosomal aberrations like break, deletion, centromeric attenuation, centric fusion and AgNOR counts in chicken bone marrow nuclei. The combined administration of enrofloxacin and Vitamin C resulted has markedly increased the mitotic index and reduced the chromosomal aberrations and AgNOR counts in the bone marrow cells.