Modulatory effects of moringa (Moringa oleifera L.) leaves infested with African mistletoe (Tapinanthus bangwensis L.) on the antioxidant, antidiabetic, and neurochemical indices in high sucrose diet-induced diabetic-like phenotype in fruit flies (Drosophila melanogaster M.).

Abstract

Moringa is a common medicinal plant tree with mistletoe infestation and its leaf is widely used as food and traditional medication in alleviating several metabolic and neurodegenerative diseases. Hence, this study investigated the influence of African mistletoe on the antioxidant, antidiabetic, and neuroprotective activities of infested moringa leaf in sucrose induced diabetes in Drosophila melanogaster model. Glucose and triglycerides were evaluated in the flies' hemolymph and all other parameters were evaluated in the tissues. A significant (p<.05) decrease in survival rate and increase in the level of glucose and triglycerides in flies fed with 30% of sucrose when compared with control was obtained. Treated flies had significant (p<.05) positive alteration in the level of glucose, triglycerides, antioxidants (both enzymatic and nonenzymatic), and enzyme activities when compared with normal and sucrose control flies. This study suggests that mistletoe infestation did not alter the antioxidant, antidiabetic, and neuroprotective effects of the moringa leaf. PRACTICAL APPLICATIONS: This present study has shown that mistletoe infestation did not alter the protective activities of moringa leaf, hence, moringa with or without mistletoe infestation could be taken as functional food to mitigate several metabolic diseases.