Abstract
Modulatory effects of curcumin, aqueous ginger extract , and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in alloxan diabetic rats.
Highlights
The present study was conducted to elucidate the hypoglycemic, hypolipidemic and antioxidant effect of curcumin, Zingiber officinale extract and their mixture in alloxan induced diabetic rats
Male albino rats (n=72) weighing (225-250 g) were divided into two main groups; first group: negative control (n=7) fed standard diet and second group: diabetic rats (n=66),which divided to five subgroups as follows: diabetic untreated rats, diabetic rats treated with curcumin (10,25,50 mg/kg.body weight), diabetic rats treated with aqueous ginger extract (50,100,200mg/kg. body weight),diabetic rats treated with their mixture and diabetic rats treated with5 mg/kg.b.w of glibenelamide
The results reported that the alloxan-induced diabetic group exhibited very highly significant (p
Summary
The present study was conducted to elucidate the hypoglycemic, hypolipidemic and antioxidant effect of curcumin, Zingiber officinale (ginger) extract and their mixture in alloxan induced diabetic rats. Treatment either curcumin or aqueous ginger extract with different doses daily for 8 consecutively weeks modulated the above changes but their mixture reported very highly significant(p
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