Abstract
Cyclooxygenase-2 is expressed on neurons in structures critically involved in the pathology of schizophrenia such as hippocampus and amygdala. With this background, the present study was designed to explore the possible effect of COX-2 inhibitor nimesulide on apomorphine-induced stereotypy and MK-801-induced hyperlocomotion in animals. Stereotypy was induced by injecting apomorphine (1 mg/kg, i.p). Mean rearing, sniffing and licking response was recorded. Locomotor activity was measured by using an actophotometer. Nimesulide (2.5–10mg/kg, i.p) was tested on these two models. To see the mechanism of action, nimesulide was combined with dopaminergic modulator apomorphine (1 mg/kg) or NMDA modulator MK-801 (0.1 mg/kg) in mice. Nimesulide was effective in combating apomorphine-induced compulsive behavior. Nimesulide also decreased the locomotor activity per se. From the above study, we concluded that nimesulide decreased apomorphine-induced stereotypy and MK-801-induced hyperlocomotion. Therefore, nimesulide may have potential adjuvant role in the drug therapy of schizophrenia. doi: 10.5214/ans.0972.7531.2005.120402
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