Abstract
Modulatory Effect of Camellia Sinensis Extract on the Function of Hypothalamic-Pituitary-Testicular Axis in PTZ-Induced Epileptic Seizures in Rat Model
Highlights
Epilepsy is a neurodevelopmental disorder that is hypothesized to arise due to exposure to a broad range of toxicants or alternation in a constellation of genetic factors
The present study aims to investigate the possible modulatory effects of Camellia sinensis extracts on the function of the Hypothalamic-Pituitary-Testicular axis in the PTZ-induced epileptogenesis rat model
The induction of epilepsy resulted in a significant increase in excitatory amino acids (Glutamate, Aspartate and Glycine) in hypothalamus as compared to control groups recording 2.84±0.3, 4.60±1.01 and 2.56±0.22 respectively at p0.05
Summary
Epilepsy is a neurodevelopmental disorder that is hypothesized to arise due to exposure to a broad range of toxicants or alternation in a constellation of genetic factors. These etiological factors can disrupt neuronal development leading to the manifestation of epileptic symptoms. Treatment of epilepsy was improved by several third-generation of antiepileptic drugs during the past decades. Opposition to antiepileptic drugs as well as the inability to resist in 20-30% of the patients led to developing new drugs or strategies for epilepsy treatment (Longhi et al, 2005; Azari et al, 2010). Many reports suggest that the usual anti-epileptic drugs can
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Egyptian Academic Journal of Biological Sciences, B. Zoology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
