Abstract
1. 1. 8-Iso-PGE 2 induced either reversible or irreversible aggregation of platelets in human platelet-rich plasma (PRP) or in the suspension of washed platelets (WP). The values of EC 50 for irreversible aggregation in PRP and WP were 4 and 2 μM, respectively. 2. 2. In rabbit PRP, 8-iso-PGE 2 (0.1-100 μM) itself did not induce or induced only reversible aggregation. 3. 3. 8-Iso-PGE 2 (0.1-20μM) potentiated adenosine diphosphate-(ADP) induced platelet aggregation in both human and rabbit. The same effect also was found for adrenaline-induced platelet aggregation in rabbit. 4. 4. The lower concentrations (0.2-0.5 μM) of 8-iso-PGE 2 decreased, and higher concentrations (1–2 μM) increased platelet aggregating factor- (PAF) induced aggregation in human PRP. In rabbit PRP, 8-iso-PGE 2 (0.02–200 μM) had only a decreasing effect on PAF-induced aggregation. 5. 5. The results suggest that low concentrations of 8-iso-PGE 2 can amplify or weaken platelet aggregation induced by various aggregatory agents.
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