Abstract
AbstractIncreased oxidative stress and inflammation are involved in the pathogenesis of several disorders including cancers and neurodegenerative diseases. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway plays an important role in mediating protection against oxidative and xenobiotic stresses. It is well established that the Nrf2 pathway induces the transcription of major phase II and cytoprotective antioxidant genes that may play a beneficial role against cancers and degenerative disorders. However, while activation of Nrf2 can provide some protection against oxidative stress and inflammation, hyperactivation of Nrf2 is associated with multiple diseases and can promote the survival and proliferation of cancer cells. Therefore, modulation of the Nrf2 pathway (inhibitors/activators) may represent a promising therapeutic strategy to counteract oxidative stress and inflammation in cancers and neurodegenerative diseases.
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