Abstract
Wound healing is a complex coordinated physiologic process involving various cytokines and growth factors that exert their influence through autocrine and paracrine pathways within the site of injury and repair. Cytokines and growth factors are polypeptide regulatory molecules that are secreted by different cell lines and are essential for normal wound healing for host defense. Conversely, they are also responsible for pathologic wound healing (abnormal scar formation and nonhealing). Modulators (eg, B-chain dimer platelet derived growth factor) are agents that influence the wound healing mechanism by creating a growth factor environment that allows optimal wound healing. The recent advances in genetic research have opened a new front in the management of chronic, nonhealing wounds. Gene therapy has a potential for localized and long-term expression of growth factors.
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