Abstract
Modulation of microphonics has recently been used to investigate the sensitivity of the utricle in the vestibular organ of the guinea pig. The same technique was used more than 30 years ago to obtain information on the processing of rotational stimuli in the horizontal semicircular canals of the pigeon. Data from that time were reanalysed to give a relation that describes the mechano-electrical transduction (MET) process in vestibular hair cells.
Highlights
To investigate the sensitivity of the guinea pig utricle to bone-conducted vibration is monitoring utricular microphonics during low-frequency hydrodynamic biasing of the position of the utricular macula. This reminded the author of the present note of work that was done more than 30 years ago [2], and where the experimental method was rotational modulation of the semicircular canal microphonics, evoked by air-conducted sound stimuli [3,4]
Due to the lowpass filter characteristics of vestibular hair cells, the AC component of the vestibular microphonic is largely attenuated at the hair cell corner frequency around 1–2 kHz [11]
Results demonstrate a reliable computational approach to approximate peripheral vestibular sensitivity and mechano-electrical transduction (MET) channel gating from the semicircular canals, analogous to the recent work by Pastras et al [1]
Summary
To investigate the sensitivity of the guinea pig utricle to bone-conducted vibration is monitoring utricular microphonics during low-frequency hydrodynamic biasing of the position of the utricular macula. This reminded the author of the present note of work that was done more than 30 years ago [2], and where the experimental method was rotational modulation of the semicircular canal microphonics, evoked by air-conducted sound stimuli [3,4]. Due to the lowpass filter characteristics of vestibular hair cells, the AC component of the vestibular microphonic is largely attenuated at the hair cell corner frequency around 1–2 kHz [11] This current work reanalyses data from the old study showing the rotational modulation of microphonics in pigeons. Results demonstrate a reliable computational approach to approximate peripheral vestibular sensitivity and MET channel gating from the semicircular canals, analogous to the recent work by Pastras et al [1]
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