Modulation of vasoactive and cytotrophic factors in developing mouse brain by pharmacological stabilization of hypoxia-inducible transcription factors (HIFs)

Abstract

Aims: Hypoxia-inducible transcription factors (HIFs) are characterized as the most important mediators of adaptive mechanisms to hypoxia. During brain development, specific HIF target genes are involved in vasculogenesis, metabolic processes, cell migration and differentiation. The aim of our ongoing study is to investigate in vivo effects of HIF stabilization on vasoactive and neurotrophic HIF-regulated factors in developing mouse brain using a prolyl hydroxylase inhibitor (PHI).