Abstract
21Jul 2020 MODULATION OF THENRF2 BINDING REGIONS THROUGH SYNTHETIC INHIBITORS Nagiasuliman M.S.c and Omer Balla Ph.D Department of Clinical Chemistry, College Of Medical Laboratory Science, Al Gezeria University, Madani, box 20, Sudan.
Highlights
Importance: NFE2 related factor 2 (NRF2) is considered as a master molecule in transcription factors cascade, whereas the activation or suppression of the NRF2 leads to control of the physiological redox stress balance
Critical Concept: NRF2 could be considered as a key to access into the chemotherapeutic resistance world this accessing it may occur through Controlling of other molecules that act on suppression, binding, and activation of the NRF2 itself
NRF2 was discovered more than two decays ago, but recently it has taken the attention of researchers when the abnormal structure and expression of the NRF2 appeared in many pathological conditions such as multiple sclerosis, chronic kidney disease or cardiovascular diseases, Alzheimer and cancer
Summary
Importance: NFE2 related factor 2 (NRF2) is considered as a master molecule in transcription factors cascade, whereas the activation or suppression of the NRF2 leads to control of the physiological redox stress balance.
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