Modulation of the transmission of signals of the rabbit septum in the presence of influences on the cholinergic system

Abstract

1. In some neurons of the medial nucleus and ventral component of the nucleus of the diagonal band (MS-DB) with stable theta-volleys, the adminstration of both eserine and cholinoblockers (scopolamine and atropine) had no influence on the effect of fine tuning of theta-cycles to the low-frequency stimulation of afferent pathways. 2. In a substantial group of cells of the MS-DB (60%) the administration of eserine, which increases the stability of theta-volleys leads to a sharp decrease of the effectiveness of electrical stimulation. In the process, the tie-in of theta-cycles to stumuli (especially the tie-in “across the pause”) is eliminated, the effects of tracking at high frequencies of stimulation characteristic of neurons with weakly expressed or absent theta-modulation are suppressed, and the initial inhibitory reactions either disappear disappeasr or are significantly shortened. 3. The administration of cholinoblockers against the background of eserine leads to the recovery of the normal reactivity of neurons of the MS-DB.