Abstract
Analysis of the gene expression program in yeast cells suggests that commitment to sporulation involves an active modulation of the gene expression program.
Highlights
Meiosis in budding yeast is coupled to the process of sporulation, where the four haploid nuclei are packaged into a gamete
The sporulation process was initiated by transferring cells to sporulation medium (SPM)
Cells that were transferred to yeast extract/peptone/ dextrose medium (YPD) after five hours in SPM continued through the second meiotic division in YPD (Figure 1e)
Summary
Meiosis in budding yeast is coupled to the process of sporulation, where the four haploid nuclei are packaged into a gamete. This differentiation process is characterized by a point of transition, termed commitment, when it becomes independent of the environment. Meiosis is characterized by a high frequency of recombination events, occurring during a prolonged prophase that separates DNA replication from the first meiotic division. This genetic exchange between homologous chromosomes ensures that they segregate properly and that the offspring differ genetically from their parents and from each other.
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