Abstract
Luteinizing hormone-releasing hormone (LHRH) analogs are widely used in reproductive medicine in order to create a hypogonadotropic hypogonadism. Besides their well-documented pituitary actions, LHRH and its agonists seem to have extrapituitary effects particularly on the ovary, placenta, and breast (1). In animals, their activity on granulosa cells is different according to the maturation state of the cells. They display an antigonadotropic effect on small follicles and a gonadotropic action on preovulatory follicles and corpus luteum, both in vivo and in vitro (2–5). Moreover, high-affinity LHRH receptors have been characterized on the internal thecal, granulosa, and luteal cells (6, 7). Their action is mainly mediated by phosphatidyl inositol hydrolysis (2, 8, 9).
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
