Abstract
Background and Aims: The Hippo pathway is a master regulator of cell survival during myocardial ischemia. Upon cellular stress, activation of Hippo signaling leads to cytosolic retention and degradation of the pro-survival transcription factor YAP. Recent evidences suggest that post-translational modifications critically affect protein functionality in conditions of cellular stress. The methyltransferase SETD7 has recently emerged as key player in the pathogenesis of vascular disease. The present study investigates whether SETD7 regulates the Hippo pathway during myocardial ischemia.
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