Modulation of the Expression of Lipogenic Activity by Malted Hungry Rice Flour (Digitaria exilis.) on Rats Induced with Obesity

Abstract

Lipolysis and lipogenesis causes obesity and these can be mediated by hormones. The study was aimed at determining the effect of malted hungry rice flour on lipogenic activity on diet-induced obese rats. The study was conducted between September to January 2021 and 2022. Twenty male adult albino rats were divided into four groups and obesity was induced which resemble mild obesity condition in human. The groups for the experiment were normal control (AIN-93), obese control, and two test diets were used to evaluate lipid profile parameter using a standard assay technique. There is an increase in BMI (from 0.37-0.41 to 0.58- 0.72). There are also an increase in other lipid profile with a decrease in HDL (p<0.05) after consumption of a palatable diet. Consumption of the test diet led to a significant reduction in the lipid profile parameter, and a significant increase in HDL cholesterol compared to the (group) obese control (p<0.05). The result suggests that malted hungry rice flour has an anti-obesity effect.