Abstract
A substance (modulating factor) which evokes the appearance of membrane potential waves in the bursting neuron RPa1 from an aestivating snail or an increase of the wave amplitude in the bursting neuron from an active snail ( Helix pomatia) has been found in the snail's brain. This factor also modulates the activity of the bursting neuron V7. The modulating factor was eluted in the exchange volume on Sephadex G-25. The application of the factor led to the development of a depolarizing current at the holding potential −55 mV under voltage clamp conditions. Hyperpolarization of the neuronal membrane from this holding potential by 7 mV for 2 s evoked an inward current before application of the modulating factor and an outward current after its application. No effect of the factor on the electrical activity of other silent or beating neurons were found. It is suggested that modulating factor may be the neurosecretory substance involved in interneuronal communication in the snail brain.
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