Abstract
To study the effect of propranolol on the Ca 2+- or Pb 2+-activated K + permeability in human erythrocytes K + effluxes were compared with single-channel currents. The results demonstrate that propranolol has a twofold effect: (1) it renders the channel protein more sensitive to Ca 2+ or Pb 2+; and (2) it simultaneously inhibits channel activity and slightly reduces single-channel conductance. The number of active channels is not affected.
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