Modulation of the autonomic nervous system for preventing perioperative atrial fibrillation: a review of literature

Abstract

Introduction: Autonomic control of the heart is exerted by the neurocardiac axis, which comprises reflexes at three levels of cardiac activity: central (higher structures of the forebrain, brainstem, and spinal cord), intrathoracic extracardiac (stellate and dorsal root ganglia), and intracardiac. Neuromodulation of the autonomic nervous system (ANS) (ganglion plexus ablation, epicardial drug infusion for temporary neurotoxicity, low-level vagus nerve stimulation, stellate ganglion blockade, baroreceptor stimulation, spinal cord stimulation, renal and pulmonary artery nerve fiber denervation) is a new therapeutic approach for managing heart rhythm disorders and cardiovascular pathologies. Atrial fibrillation (AF) occurs in up to 30% of patients after open cardiac surgery and is associated with increased morbidity and mortality in the long-term follow-up. Objective: To evaluate the safety and efficacy of the different neuromodulation approaches for preventing postoperative atrial fibrillation (POAF) in clinical and experimental settings.Conclusion: ANS neuromodulation techniques have demonstrated high efficacy and safety for preventing POAF. Received 21 August 2023. Revised 16 October 2023. Accepted 31 October 2023. Funding: The study was supported by Russian Science Foundation (project No. 22-25-00672). Conflict of interest: The authors declare no conflict of interest. Contribution of the authorsConception and study design: V.V. Shabanov, A.G. Filippenko, V.V. BeloborodovDrafting the article: V.V. Shabanov, A.G. Filippenko, T.U. Khalkhoghaev, V.I. MurtazinCritical revision of the article: V.V. ShabanovFinal approval of the version to be published: V.V. Shabanov, V.V. Beloborodov, T.U. Khalkhoghaev, V.I. Murtazin, A.G. Filippenko