Abstract
Mauritia flexuosa (buriti) is a typical Brazilian palm tree found in swampy regions with many plant forms. The fruit has various purposes with the pulps to the seeds being used for ice creams, sweets, creams, jellies, liqueurs, and vitamin production. A physicochemical characterization of the fixed pulp oil and its antibacterial and aminoglycoside antibiotic modifying activity against Gram-positive and Gram-negative multiresistant bacterial strains were performed using broth microdilution assays. Physical properties, such as moisture, pH, acidity, peroxide index, relative density, and refractive index, indicated oil stability and chemical quality. In the GC/MS chemical composition analysis, a high content of unsaturated fatty acids (89.81%) in relation to saturated fatty acids (10.19%) was observed. Oleic acid (89.81%) was the main fatty acid identified. In the antibacterial test, the fixed oil obtained the Minimum Inhibitory Concentration (MIC) ≥ 1024 μg/mL for all standard and multiresistant bacterial strains. The synergic effect of fixed pulp oil combined was observed only in Staphylococcus aureus SA–10, with an MIC reduction of the gentamicin and amikacin by 40.00% and 60.55%, respectively. The data indicates the M. flexuosa fixed oil as a valuable source of oleic acid and modulator of aminoglycoside activity.
Highlights
In the antibacterial activity test, the results showed high Minimum Inhibitory Concentration (MIC) values ≥1024 μg/mL for all
In the antibacterial activity test, the results showed high MIC values ≥1024 μg/mL for all standard standard and multiresistant bacterial strains (Table 4)
The data obtained shows the M. flexuosa fixed pulp oil to be a valuable source of oleic acid and indicates an aminoglycoside antibiotic modulatory potential
Summary
The increase in microorganisms resistant to clinically important antimicrobials, such as aminoglycosides, have been challenging science and causing serious public health risks [1].Pathogens 2018, 7, 98; doi:10.3390/pathogens7040098 www.mdpi.com/journal/pathogensSevere toxicity is one of the aminoglycoside resistance problems associated with high doses or chronic treatment leading to ototoxicity and/or nephrotoxicity [2].Aminoglycosides are antibiotics with a mechanism of action based on protein synthesis, where by binding to the 30S prokaryotic ribosome, these prevent adequate mRNA translation [2].Despite a wide bactericidal spectrum and benefits in the treatment of many infectious disorders that exist, bacterial resistance to aminoglycosides has become a problem in recent decades [3].Due to aminoglycoside resistance, many plants have been studied not just for their antibacterial activity, and for their modifying action. Severe toxicity is one of the aminoglycoside resistance problems associated with high doses or chronic treatment leading to ototoxicity and/or nephrotoxicity [2]. Aminoglycosides are antibiotics with a mechanism of action based on protein synthesis, where by binding to the 30S prokaryotic ribosome, these prevent adequate mRNA translation [2]. Despite a wide bactericidal spectrum and benefits in the treatment of many infectious disorders that exist, bacterial resistance to aminoglycosides has become a problem in recent decades [3]. Many plants have been studied not just for their antibacterial activity, and for their modifying action. Natural plant products can alter antibiotic effects by improving or decreasing their activity such that these products can be a viable alternative for the resistance issue [4,5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
