Abstract
Until now, the focalization of liver diseases has remained a mystery. Although many patients have risk factors such as viral hepatitis B&C, alcohol consumption, drugs and fatty liver disease, but little number of patients has no obvious risk factors. Telomere shortening limits, hepatocyte regenerative potential during chronic liver dysfunctions, and cirrhosis is linked with hepatocellular senescence. Shortening of Telomere and its ordinance plays a critical role in tissue regeneration during ageing, chronic disorders, and tumor progression and promotion. Telomere shortening is arrested by a special type of holoenzyme called telomerase whose task is to carry out the end replication by de novo synthesis of telomeric repeats. To target this holoenzyme, recent evidence suggests that certain natural compounds potentially suppress the transcription of hTERT (human telomerase reverse transcriptase) subunit. Therefore, this property can be utilized efficiently for the treatment of cancer. This review summarizes current knowledge about telomerase complexes and tries to give an update on telomerase expression modulation in response to certain natural compounds in liver cancer.
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