Abstract
Since neurodevelopmental disorders (NDDs) influence more than 3% of children worldwide, there has been intense investigation to understand the etiology of disorders and develop treatments. Although there are drugs such as aripiprazole, risperidone, and lurasidone, these medications are not cures for the disorders and can only help people feel better or alleviate their symptoms. Thus, it is required to discover therapeutic targets in order to find the ultimate treatments of neurodevelopmental disorders. It is suggested that abnormal neuronal morphology in the neurodevelopment process is a main cause of NDDs, in which the serotonergic system is emerging as playing a crucial role. From this point of view, we noticed the correlation between serotonin receptor subtype 7 (5-HT7R) and NDDs including autism spectrum disorder (ASD), fragile X syndrome (FXS), and Rett syndrome (RTT). 5-HT7R modulators improved altered behaviors in animal models and also affected neuronal morphology via the 5-HT7R/G12 signaling pathway. Through the investigation of recent studies, it is suggested that 5-HT7R could be a potential therapeutic target for the treatment of NDDs.
Highlights
Neurodevelopmental disorders (NDDs) are a group of disorders characterized by abnormal brain developmental processes which affect emotion, learning, cognition, and memory [1]
Neuronal processes, including outgrowth of dendrites and axons, are critical steps during early development [9] and alterations in the dendritic structure were found in multiple animal models of NDDs [10,11,12,13], which demonstrates a close relationship between neuronal morphology defects and NDDs
We investigate the relationship between serotonin receptor subtype 7 (5-HT7 R) as a therapeutic target and various NDDs including autism spectrum disorder (ASD), Rett syndrome (RTT), and fragile X syndrome (FXS)
Summary
Neurodevelopmental disorders (NDDs) are a group of disorders characterized by abnormal brain developmental processes which affect emotion, learning, cognition, and memory [1]. Ruchhoeft and co-workers examined the effects of Rho GTPases on dendrite formation and growth cone morphology using Xenopus retinal ganglion cells (RGCs) expressed with wild-type, mutant RhoA, Rac, and Cdc42 [27]. The analysis of expressed inCdc the early and substantially diminished by almost up toInninefold in the growth cone morphology, growth cones overexpressed with wt-Cdc had more filopodia later stage, but Gs protein was not affected during the development process. These exand had larger back branches than controls, expressing mutant.
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