Abstract
Previous studies have shown that treatment of SHR (spontaneously hypertensive) rats with the antihypertensive drugs captopril, hydralazine and terazosin results in changes in the specific activities of the antioxidant enzymes glutathione peroxidase, catalase and CuiZn superoxide dismutase in liver and myocardium. In order to determine if these changes were caused by alterations in the levels of the mRNAs for these enzymes, the tissue levels of the antioxidant enzyme mRNAs were measured by a quantitative ribonuclease protection assay procedure. In myocardium, all three drug treatments significantly increased CuiZn superoxide dismutase mRNA but decreased glutathione peroxidase mRNA levels, and hydralazine and terazosin decreased myocardial catalase mRNA levels. In liver, all three drugs changed glutathione peroxidase mRNA levels, whereas only captopril treatment changed the CuiZn superoxide dismutase mRNA level, and none of the drug treatments affected catalase mRNA levels. With the exceptions of the effects of captopril and hydralazine on liver CuiZn superoxide dismutase and catalase mRNA levels respectively, the data for the mRNA levels paralleled previously reported changes for tissue enzyme specific activities, suggesting that these changes are. in most cases, caused by changes in the levels of the mRNAs for the enzymes.
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