Abstract
The family of poly (ADP-ribose) polymerase (PARP) enzymes have been implicated in many important cellular processes including repairing DNA damage caused by various injury factors such as chemotherapy or radiation. The DNA repair process involves a rapid activation of PARPs by DNA strand breaks, poly (ADP-ribose) lation of PARPs as well as histone and other nuclear kinases, and recruitment of repair enzymes. ABT-888 is a potent inhibitor of PARP-1 and 2 enzymes. Although as single agent, it has no anti-proliferative effect, it has been shown that ABT-888 augmented the antitumor activity of DNA-damage drugs in various human tumors in preclinical studies.
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