Abstract
Endogenous and deuterium labelled acetylcholine (ACh) and choline (Ch) in the neostriatum were chemically assayed after radio-frequency lesions in the substantia nigra-ventral tegmental area and in the B7 or B8 5-hydroxytryptamine (5-HT) regions of the brainstem. Lesions in the substantia nigra-ventral tegmental region or in the B7 area, which provide dopamine (DA) and 5-HT afferents to the caudate-putamen nucleus, respectively, caused a decrease in 2H 9-ACh synthesis, while endogenous levels of ACh and Ch were unchanged. A unilateral lesion of the B8 5-HT region, which projects in part to the substantia nigra, produced an increase in endogenous ACh levels, as well as a decrease in 2H 9-ACh synthesis on the side ipsilateral to the lesion. On the basis of these data, we conclude that DA and 5-HT projections to the caudate-putamen nucleus have a net excitatory effect on cholinergic interneurons in that area. Furthermore, we suggest that the putative B8 5-HT projection is excitatory upon nigral neurons that, in turn, project to the neostriatum.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.