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Abstract
The aim of this study was to determine wether the maintenance of thermogenesis induced by oleoyl-estrone was mediated by modulation of the expression of UCPs. Female adult Zucker lean rats(220-230 g) were used. Osmotic minipumps were inserted under the skin on the rats and connected to the left jugular vein. They delivered a lipid dropled suspension containing oleoyl-estrone (3.5 mmol/kg day, treated) or only the vehicle (control animals). Two weeks after the implantation of the pumps, samples of interscapular brown adipose tissue (BAT) and muscles extensor digitorum longus, tibialis anterior and soleus were obtained and UCP1, UCP2 and UCP3 mRNAs determined by Northern blot. Oleoyl-estrone treatment does not modify UCP1 or UCP2 expression and provokes significant changes in UCP3 expression: increases in BAT and the red-fibre soleus muscle, decreases in the white and red-fibre tibialis anterior muscle and remains unchanged in the white- fibre extensor digitorum longus muscle.
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