Modulation of mTORC1 and IL-6 following mirror therapy and pregabalin in complex regional pain syndrome type 1.

Abstract

Aim: The study was designed to evaluate the modulation of mTORcomplex 1 (mTORC1) and IL-6genes following the use of mirror therapy (MT) and pregabalin in complex regional pain syndrometype-1 patients. Materials & methods: Two groups of 20 patients: MTgroup received MT and pregabalin, control therapygroup received pregabalin. Neuropathic pain symptom inventory (NPSI), numeric rating scale- pain, modified motor activity log, SF-12 questionnaire for quality of lifeand IL-6 and mTORC1 expression were evaluated. Results: Group MTdemonstrated a statistically significant improvement in NPSI burning, NPSI allodynia and numeric rating scale pain scores, modified motor activity logand SF-12 scores. Significant downregulation of mTORC1 and IL-6 observed in both. Conclusion: MTis a significant adjunct to pregabalin in improving motor function, quality of life and alleviating pain in complex regional pain syndrome type 1. Clinical Trial Registration: CTRI/2019/01/017272(ClinicalTrials.gov).