Modulation of lipid peroxidation, hypolipidemic and antioxidant activities in brain tissues of diabetic rats by fibre – Enriched biscuits

Abstract

ObjectiveTo investigate the effect of feeding fibre – enriched biscuit on the antioxidant and hypolipidemic activities in brain tissues of diabetic rats. MethodDiabetes was induced by a single intraperitoneal injection of alloxan. Treatment lasted for 14 d, after which the rats were sacrificed by cervical dislocation. Brain tissues were used for the assessment of GSH, catalase, SOD and lipid peroxidation as well as lipid profiles. ResultInduction of diabetes led to a significant decrease in GSH level, elevated SOD and catalase activities. These were significantly modified by the biscuits. There was an elevated level of malondialdehyde in the brain tissues of the untreated diabetic rats; this was significantly reduced by the biscuits. There was a significant decrease in HDL and a significant increase in LDL levels, total cholesterol and triglycerides in the untreated (diabetic) rats. Feeding with fibre – enriched biscuits led to decrease in the levels of total cholesterol, triglyceride, LDL – cholesterol and caused a significant increase in the levels of HDL. ConclusionsThese results suggest a therapeutic and protective effect of the fibre – enriched biscuits against diabetic – induced brain toxicity in rats.