Abstract
OPINION article Front. Physiol., 20 December 2012Sec. Membrane Physiology and Membrane Biophysics Volume 3 - 2012 | https://doi.org/10.3389/fphys.2012.00477
Highlights
Heme oxygenases, the inducible heme oxygenase-1 (HO-1), are the subject of intensive research since they show great promise as cytoprotective agents
The physiological roles and potential of carbon monoxide (CO) in particular are currently topics of intense research, with clinical trials currently evaluating its safety in human subjects and its usefulness in treating a variety of disorders (Wu and Wang, 2005; Durante et al, 2006; Kim et al, 2006; Ryter et al, 2006)
I draw upon some recent examples of ion channel/transporter modulation by CO in the cardiovascular and central nervous systems in order to compare the beneficial and deleterious cellular effects of CO, and to examine whether we should be concerned about the therapeutic index of CO
Summary
The inducible heme oxygenase-1 (HO-1), are the subject of intensive research since they show great promise as cytoprotective agents. I draw upon some recent examples of ion channel/transporter modulation by CO in the cardiovascular and central nervous systems in order to compare the beneficial and deleterious cellular effects of CO, and to examine whether we should be concerned about the therapeutic index of CO.
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