Abstract
Modulation of Inflammation by Alcohol Exposure
Highlights
Their model suggests that cytokines, chemokines, oxidative stress, and microbial flora play a role in the development and progression of alcoholic liver disease
The review describes the link between the derived endotoxins and the activation of Kupffer cells through the LPS/Toll-like receptor (TLR) 4 pathways
Kasztelan-Szczerbinska and coworkers investigate serum levels of adiponectin, leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as alcoholic liver disease (ALD) complications in inpatients. Their data revealed both changes in some of these mediators and in difference in sex, which shows that the leptin concentrations may play a role in the observed sex difference in the development of ALD
Summary
M. Chen, entitled “Intoxication by intraperitoneal injection or oral gavage potentiate postburn organ damage and inflammation” reveals that the route of administration of alcohol (oral gavage versus intraperitoneal injection) effects postburn responses. They showed comparable systemic changes including the hematologic response and serum levels of proinflammatory mediators, including interleukin-6 (IL-6). In a review entitled “The effect of inflammatory cytokines in alcoholic liver disease,” H.
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